Dynamic Change of Myogenin in Denervated Rat Mimetic Muscle

Takehiro Warabi; Hiroshi Furukawa; Ryuji Shichinohe; Toshihiko Hayashi; Yuhei Yamamoto

doi:10.1055/s-0035-1549284

Facial Plastic Surgery, Table of Contents

Facial Plast Surg 2015; 31(02): 152-159
DOI: 10.1055/s-0035-1549284

Rapid Communication

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Dynamic Change of Myogenin in Denervated Rat Mimetic Muscle

Authors

Takehiro Warabi

¹Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Hokkaido, Sapporo, Japan
Hiroshi Furukawa

¹Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Hokkaido, Sapporo, Japan
Ryuji Shichinohe

¹Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Hokkaido, Sapporo, Japan
Toshihiko Hayashi

¹Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Hokkaido, Sapporo, Japan
Yuhei Yamamoto

¹Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Hokkaido, Sapporo, Japan

Abstract

We previously reported double innervation of rat mimetic muscles with labeling of facial nuclei. However, whether denervated mimetic muscles are affected after such nerve repair is not known. Rats were divided into five groups: Group A, controls; Group B, complete facial palsy; Group C, complete facial palsy with repair using end-to-end neurorrhaphy; Group D, incomplete facial palsy; and Group E, incomplete facial palsy with repair using end-to-side neurorrhaphy. Preoperatively and postoperatively, facial palsy and myogenin (Myog) expression in mimetic muscles were evaluated. Expression peaked on day 7 in Group B but was lower in Groups C and D. Expression in Groups D and E was comparable on day 28, and each model's score showed characteristic changes. Myog expression in facial mimetic muscles increases with denervation and decreases with nerve repair. Determining Myog expression levels in mimetic muscles just after nerve repair may help surgeons predict postoperative prognosis in facial palsy.

Keywords

myogenin - facial palsy - reinnervation

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References

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